Table 1.
Minimum inhibitory concentrations (MIC) of crude extracts of A. californica, sesamin, and asarinin against Mycobacterium species
| Sample | MIC (µg/mL) Against: | ||||
|---|---|---|---|---|---|
| M. smegmatis | M. abscessus | M. chelonae | M. marinum | M. avium A5 | |
| Sample 1a | 125 | >250 | >250 | 250 | 125 |
| Sample 2a | >250 | >250 | >250 | >250 | >250 |
| Sample 3b | 125 | >250 | 250 | >250 | >250 |
| Sesamin | 8 | >130 | 65 | 13 | 8 |
| Asarinin | 35 | >140 | 140 | 35 | 35 |
| Rifampinc | 25 | 0.8 | 0.15 | 0.8 | 2 |
a
Samples 1 and 2 are for root and aerial extracts-respectively from the same A. californica plant.
b
Sample 3 represents a large batch root extract that was subjected to bioactivity-directed fractionation, resulting in the isolation of sesamin and asarinin.
c
The antibiotic rifampin is included as a positive control. Negative control (vehicle, 2% DMSO) caused no significant growth inhibition.