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Proposed model. At baseline, the VNN1 gene is modestly expressed and this level of expression is not altered in stable asthma or acute asthma. During treatment for acute asthma exacerbation, corticosteroid treatment induces DNA methylation at the CpG4 site of the VNN1 gene promoter, enhancing the expression of VNN1 gene. Enhanced VNN1 expression contributes to optimal response to corticosteroid treatment.
