Fig. 5.

Onset of axonal injury. A) By 3 h after blast, YFP+ bulbs have formed in the dCST, but are much smaller and far less numerous than at 2 days after blast. B, C) By 6 h post-blast, YFP+ bulbs are more abundant and more obviously clustered than at 3 h. The YFP+ bulbs are also larger than at 3 h, but still considerably smaller than at 2 days. (Note that the images in Fig. 5A–C are at twice the magnification of those in Fig. 4B–D.) In C, several YFP+ bulbs that are also βAPP+ are marked by arrows. D) A few RMO14+ axonal profiles are present in the lateral white matter at 6 h after blast. The scattered YFP+ axons belong to the dorsolateral component of the CST. Scale bar in D = 100 μm for D; 67 μm for A–C.