Table 1. KRAS mutations observed in human cancer in order of decreasing frequency (http://www.sanger.co.uk/cosmic; accessed 14th July 2015).
KRAS genotype | Mutation | Cases | Frequency |
---|---|---|---|
G12D | c.35G>A | 10719 | 33.8% |
G12V | c.35G>T | 7138 | 22.5% |
G13D | c.38G>A | 3959 | 12.5% |
G12C | c.34G>T | 3713 | 11.7% |
G12A | c.35G>C | 1694 | 5.3% |
G12S | c.34G>A | 1507 | 4.7% |
G12R | c.34G>C | 1024 | 3.2% |
G13C | c.37G>T | 276 | 0.9% |
Q61H | c.183A>C | 144 | 0.5% |