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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Nanomedicine. 2015 Jun 24;11(7):1821–1829. doi: 10.1016/j.nano.2015.06.003

Figure 1.

Figure 1

(A) The diagram of two-magnet setup used to study movement of MNPs in brain tissue. The tissue loaded with MNPs was mounted and visualized under a fluorescence microscope after exposing it to the uniform magnetic field (B) An illustration of how MNPs behave in brain tissue with and without an applied uniform magnetic field. The MNPs diffuse in different directions (blue arrows) in the absence of a uniform magnetic field (left, top). After the introduction of the magnetic field, the MNPs move towards each other due to an overlap of induced magnetic fields of influence (green circles). As a result, the MNPs form chains as they move towards each other and longer chains have a larger field of influence which recruits additional particles to the chain (bottom). (C) Chaining of MNPs experimentally observed in mouse brain tissue (pre-frontal cortex region) in the presence of a uniform magnetic field. The MNP chains (orange) and the barely-visible single MNPs are marked by white ovals and white dotted circles respectively. The dendrites (green) in the tissue are indicated by white arrows.