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. 2015 Aug 3;95(10):1117–1129. doi: 10.1038/labinvest.2015.94

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Copyright © 2015 United States & Canadian Academy of Pathology

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t-PA promotes efficient resolution of acute hepatic injury in mice. C57Bl/6 (WT) and t-PA null mice (t-PA KO) analyzed at days 1–7 and 14 post-CCL₄ injury as described in MATERIALS AND METHODS. (a) Serum ALT values in WT and t-PA KO mice. No values were significantly different at time points indicated. (b) Quantification of α-SMA staining (× 20 images, minimum 10/animal). Sections from WT and KO mice on matching days were stained, imaged, and analyzed together. Representative images are shown. Error bars±s.e.m. *P<0.05, **P<0.01, ***P<0.001, unpaired Student's t-test. Scale bars, 50 μm.

t-PA promotes efficient resolution of acute hepatic injury in mice. C57Bl/6 (WT) and t-PA null mice (t-PA KO) analyzed at days 1–7 and 14 post-CCL₄ injury as described in MATERIALS AND METHODS. (a) Serum ALT values in WT and t-PA KO mice. No values were significantly different at time points indicated. (b) Quantification of α-SMA staining (× 20 images, minimum 10/animal). Sections from WT and KO mice on matching days were stained, imaged, and analyzed together. Representative images are shown. Error bars±s.e.m. *P<0.05, **P<0.01, ***P<0.001, unpaired Student's t-test. Scale bars, 50 μm.