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. 2015 Sep 29;5:208. doi: 10.3389/fonc.2015.00208

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Copyright © 2015 Slavin, Niell-Swiller, Solomon, Nehoray, Rybak, Blazer and Weitzel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clinical cancer genetics community of practice experience with multigene panel tests. 403 results of 348 commercial multigene panel tests ordered by Clinical Cancer Genetics Community of Practice clinicians between January 1, 2014, through October 1, 2014 are depicted. “VUS” means variant of uncertain significance. “Uninformative” refers to negative panel testing results. “Inconclusive” refers to the laboratories inability to classify the result into other categories at the present time. The plus symbol (+) denotes that six patients had mutations in ≥1 gene. Asterisk (*) denotes that 35 patients had ≥1 VUS. The side table shows the number of individual positive gene mutations found. (φ) denotes that five MUTYH cases were monoallelic, whereas one case was biallelic.