Risk of bias assessment tool. (A) Across trials, information is either from trials at low risk of bias (green), or from trials at unclear risk of bias (yellow), or from trials at high risk of bias (red). (B) For each study, every bias domain will be checked, the given summary represents an assessment of bias risk across studies. For each bias domain, low risk of bias means that information is from studies at low risk of bias (green), high risk of bias indicates the proportion of information from studies at high risk of bias which might be sufficient to affect the interpretation of the results (red), and unclear risk of bias refers to information from studies at low or unclear risk of bias (yellow).