Table 1 . Physiological and Biochemical Variables for Various Treatment Groups .

Variables LPS (µg)	50 min Ischemia by applying LAD tourniquet								sTNFαR 100 µg (n = 8)
None (n = 15)	0.1 µg (n = 8)	0.3 µg (n = 8)	1.0 µg (n = 8)	10 µg (n = 8)	30 µg (n = 8)	100 µg (n = 15)	300 µg (n = 8)
Left Ventricle Contractile Function
+dP/dT (mm Hg/s)	1422±844	1752±967	1733±1021	1499±1211	1321 ± 1201	1354±1380	1002±488	762±348	989±1004
SS (ISW) %	-5.3 ± 1.2	0.1 ± 1.5*	0.2 ± 1.6*	-2.5 ± 1.3	-3.4 ± 1.5	-4.8 ± 1.8	-5.9 ± 2.4	-6.8 ± 2.1	-5.1 ± 2.3
SS (NIW) %	15.1 ± 4.2	18.5 ± 5.1	16.8 ± 5.3	14.1 ± 5.2	11.1 ± 3.5	12.3 ± 5.3	6.4 ± 3.8 *	5.2 ± 2.0 *	5.9 ± 3.1
Left Ventricle Relaxation
-dP/dT (mm Hg/s)	1022±944	1688±912	1622±895	1411±962	1123±745	1098±591	781±355	512±452	1032 ±854
IVRT (msec)	102 ± 64	86 ± 91	101 ± 84	109 ± 91	126 ± 95	116 ± 86	205 ± 101	311 ± 124	131 ± 96
Inflammatory Cytokines and myocardial Injury Biomarkers
TNFα (pg/mL)	180 ± 56	345 ±79	434 ± 102	604 ± 362	893 ± 330	988±287	2350±1220	2403±1340	2421±1620
cTnI (ng/dL)	10.1 ± 3.2	10.2 ± 4.1	11.2 ± 7.6	18.9 ± 10.2	25.6 ± 13.1	31.2 ± 6.9*	37.5± 5.1†*	37.4 ± 8.1*	9.5 ± 3.6†
MDA (pg/mL)	180 ± 25	NM	NM	NM	NM	NM	650 ± 253 †*	2770±1240 *	285 ± 115†
MDA (pg/mL)	180 ± 25	NM	NM	NM	NM	NM	NM	NM	NM

All cardiac variables measured after 4 hours of reperfusion to examine the contractile and relaxation functions of the heart, as well as the marker of myocardial injury. Markers of myocardial contraction included derivatives of the left ventricle (LV) pressure over the derivatives of time during systole (+dP/dT) and the percent segment shortening (SS) of the anterior ischemic wall (ISW) and the posterior non-ischemic wall (NIW). In order to assess the relaxation of the LV, negative values of dP/dT were measured during diastole along with isovolumetric relaxation time in millisecond. Biomarkers of cellular injury and inflammation included serum concentrations of tumor necrosis factor alpha (TNFα, which are expressed in pg/mL, cardiac troponin I (cTnI) and malondialdehyde (MDA), a marker of lipid peroxidation, which is also expressed in pg/mL of tissue homogenate. Asterisks indicate a significant difference (P < .05), when a comparison was made to the ischemia controls (IS) and † indicates significant difference (P < .05), when a comparison was made between the groups treated with soluble receptor of TNFα to their normal saline-treated control (IS + LPS 100 µg).