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. 2015 Sep 11;12(9):11422–11447. doi: 10.3390/ijerph120911422
(a) Summary Based on Literature Search and Interviews with Experts
Protection Goals Fire Blight Control Measures
Biological Control Chemical Control Conventional Breeding a GMO b
Commercial Name Composition Blossom Protect A. pullulans Copper Myco-sin Aluminum Sulfate LMA Potassium Aluminum Sulfate Strepto, Firewall, Streptomycin Sulfate 1 gene 2 gene 1 gene 2 genes
“Ladina” FB_F7 QTL FB_F7 QTL + ?? “Gala” + FB_MR5 c “Gala” + FB_MR + ??
FB-free agricutural crop and environment
 Feasibility E d E E E E E possible E possible
 Efficacy of method 73–78% 34–88% 51–65% 73% 76–89% 60–75% ? e 93–100% ?
 Durability high high high high resistant strains? virulent strains? virulent strains? virulent strains? virulent strains?
Protection of consumer and workers AT f AT AT AT AT + resistance? g Allergy? ? ?
no tests required
Protection of environment
 Impact on exposed animals low low low low low low low low low
 Impact on biodiversity low medium medium medium low low low low low
 Impact on soil and water low medium medium medium medium low low low low
Economic interest (acceptance)
 Quality accepted and desired by consumer medium medium high high medium high high low low
 Way of production acceptable for consumer high high high high medium high high low low
Maitain cultivar diversity and diversity of cultivation practices
 Impact of method on cv diversity low medium medium low low high high high high
 Impact of method on cultivation practices low medium medium medium medium low low low low

Green: no or negligible problems identified; Yellow: minor uncertainties and/or minor problems identified; Orange: Uncertainties and/or problems identified that urgently need to be addressed. a: Conventional breeding: apple cultivars carrying a one or two gene-based FB resistance obtained by conventional breeding; b: GMO: Genetically Modified Organism carrying a one or two gene-based FB resistance; c: “Gala” + FB_MR5: estimations based on transgenic lines tested under greenhouse conditions with two E. amylovora strains; d: E: Product already exists; e: ?: Unknown; f: AT: Safety of product tested for registration. If used according to instructions no problems for workers and consumers; g: Acquisition of antibiotic (multi) resistant bacteria in operators not tested.