Table 3.
Genotype and allele distributions in patients with T2DM and control subjects.
| Variants | Total | Male | Female | ||||||
|---|---|---|---|---|---|---|---|---|---|
| T2DM n (%) | Control n (%) | p value | T2DM n (%) | Control n (%) | p value | T2DM n (%) | Control n (%) | p value | |
| rs12255372 | |||||||||
| Genotyping | |||||||||
| GG | 572 (65.2) | 611 (70.2) | 344 (63.5) | 399 (71.0) | 228 (68.1) | 212 (68.6) | |||
| GT | 270 (30.8) | 238 (27.3) | 172 (31.7) | 152 (27.0) | 98 (29.2) | 86 (27.8) | |||
| TT | 35 (4.0) | 22 (2.5) | 0.044 * | 26 (4.8) | 11 (2.0) | 0.004 * | 9 (2.7) | 11 (3.6) | 0.773 |
| Dominant model | |||||||||
| GG | 572 (65.2) | 611 (70.2) | 344 (63.5) | 399 (71.0) | 228 (68.1) | 212 (68.6) | |||
| GT+TT | 305 (34.8) | 260 (29.8) | 0.028 * | 198 (36.5) | 163 (29.0) | 0.008 * | 107 (31.9) | 97 (31.4) | 0.881 |
| Recessive model | |||||||||
| TT | 35 (4.0) | 22 (2.5) | 26 (4.8) | 11 (2.0) | 9 (2.7) | 11 (3.6) | |||
| GG+GT | 842(96.0) | 849 (97.5) | 0.085 | 516 (95.2) | 551 (98.0) | 0.009 * | 326 (97.3) | 298 (96.4) | 0.523 |
| Additive model | |||||||||
| GG | 572 (65.2) | 611 (70.2) | 344 (63.5) | 399 (71.0) | 228 (68.1) | 212 (68.6) | |||
| GT | 270 (30.8) | 238 (27.3) | 172 (31.7) | 152 (27.0) | 98 (29.2) | 86 (27.8) | |||
| TT | 35 (4.0) | 22 (2.5) | 0.014 * | 26 (4.8) | 11 (2.0) | 0.002 * | 9 (2.7) | 11 (3.6) | 0.939 |
| Allele | |||||||||
| G | 1414 (80.6) | 1460 (83.8) | 860 (79.3) | 950 (84.5) | 554 (82.7) | 510 (82.5) | |||
| T | 340 (19.4) | 282 (16.2) | 0.013 * | 224 (20.7) | 174 (15.5) | 0.002 * | 116 (17.3) | 108 (17.5) | 0.939 |
| rs7901695 | |||||||||
| Genotyping | |||||||||
| TT | 535 (61.0) | 586 (67.3) | 325 (60.0) | 380 (67.6) | 210 (62.7) | 206 (66.7) | |||
| TC | 295 (33.6) | 262 (30.1) | 184 (33.9) | 171 (30.4) | 111 (33.1) | 91 (29.4) | |||
| CC | 47 (5.4) | 23 (2.6) | 0.002 * | 33 (6.1) | 11 (2.0) | <0.001 * | 14 (4.2) | 12 (3.9) | 0.570 |
| Dominant model | |||||||||
| TT | 535 (61.0) | 586 (67.3) | 325 (60.0) | 380 (67.6) | 210 (62.7) | 206 (66.7) | |||
| TC+CC | 342 (39.0) | 285 (32.7) | 0.006 * | 217 (40.0) | 182 (32.4) | 0.008 * | 125 (37.3) | 103 (33.3) | 0.291 |
| Recessive model | |||||||||
| CC | 47 (5.4) | 23 (2.6) | 33 (6.1) | 11 (2.0) | 14 (4.2) | 12 (3.9) | |||
| TT+TC | 830 (94.6) | 848 (97.4) | 0.004 * | 509 (93.9) | 551 (98.0) | <0.001 * | 321 (95.8) | 297 (96.1) | 0.849 |
| Additive model | |||||||||
| TT | 535 (61.0) | 586 (67.3) | 325 (60.0) | 380 (67.6) | 210 (62.7) | 206 (66.7) | |||
| TC | 295 (33.6) | 262 (30.1) | 184 (33.9) | 171 (30.4) | 111 (33.1) | 91 (29.4) | |||
| CC | 47 (5.4) | 23 (2.6) | 0.001 * | 33 (6.1) | 11 (2.0) | 0.001 * | 14 (4.2) | 12 (3.9) | 0.338 |
| Allele | |||||||||
| T | 1365 (77.8) | 1434 (82.3) | 834 (76.9) | 931 (82.8) | 531 (79.3) | 503 (81.4) | |||
| C | 389 (22.2) | 308 (17.7) | 0.001 * | 250 (23.1) | 193 (17.2) | 0.001 * | 139 (20.7) | 115 (18.6) | 0.335 |
* p <0.05.