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. 2015 Sep 28;210(7):1085–1099. doi: 10.1083/jcb.201503006

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© 2015 Pacquelet et al.

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Figure 2. — Inhibition of centralspindlin or astral microtubule pathway does not account for furrow mispositioning. (A) Inactivation of the astral microtubule pathway by nop-1 and let-99 RNAi does not inhibit furrow ingression in cul-5(ok1706) par-4(it47) one-cell embryos. nop-1 and let-99 RNAi effectively inhibited astral microtubule signaling as judged by their ability to inhibit furrow ingression in zen-4(or153) mutant. (B) Inactivation of the centralspindlin pathway by zen-4 RNAi partially inhibits furrow ingression in cul-5(ok1706) par-4(it47) one-cell embryos. zen-4 RNAi effectively inhibited centralspindlin signaling as the furrow regresses in zen-4(RNAi) embryos and does not ingress in nop-1(it142); zen-4(RNAi) embryos. (C–F) Inactivation of centralspindlin or the astral microtubule pathway does not shift the furrow toward the anterior. Furrow position was measured in zen-4(or153) and nop-1(it142) mutants (C) and in wild-type, cul-5(ok1706), or par-4(it47) embryos treated with zen-4 (D), nop-1 (E), or let-99 (F) RNAi. Furrow position was measured when the furrow spanned the entire embryo. P-values from Student’s t test.