. 2015 Jul 3;7(3):1191–1214. doi: 10.3390/cancers7030833

Table 1.

Predictors of chemotherapy toxicity in the elderly.

CRASH	CARG
Hematologic Scores ○ Diastolic BP ○ IADL ○ LDH ○ Chemotox Non-hematologic Scores ○ ECOG PS ○ MMS ○ MNA ○ Chemotox	Age >72 years Cancer type: GI or GU Standard chemotherapy dosing Polychemotherapy (>1 chemotherapy drug) Hemoglobin ○ <10 g/dL (females) ○ <11 g/dL (males) Creatinine clearance <34 mL/min (Jelliffe) Hearing impairment, fair or worse Functional impairment ○ >1 fall in 6 months ○ IADL: some help or unable to take medications ○ MOS: limited walking to 1 block ○ MOS: decreased social activities due to physical or emotional health

CRASH

CARG

Hematologic Scores
- ○
  Diastolic BP
- ○
  IADL
- ○
  LDH
- ○
  Chemotox
Non-hematologic Scores
- ○
  ECOG PS
- ○
  MMS
- ○
  MNA
- ○
  Chemotox

Age >72 years
Cancer type: GI or GU
Standard chemotherapy dosing
Polychemotherapy (>1 chemotherapy drug)
Hemoglobin
- ○
  <10 g/dL (females)
- ○
  <11 g/dL (males)
Creatinine clearance <34 mL/min (Jelliffe)
Hearing impairment, fair or worse
Functional impairment
- ○
  >1 fall in 6 months
- ○
  IADL: some help or unable to take medications
- ○
  MOS: limited walking to 1 block
- ○
  MOS: decreased social activities due to physical or emotional health

BP: Blood pressure; IADL: Instrumental activities of daily living; LDH: Lactate dehydrogenase; ULN: Upper limit of normal; Chemotox: Chemotoxicity of the regimens were calculated using an index to estimate the average per-patient risk of chemotherapy toxicity; ECOG PS: Eastern Cooperative Oncology Group performance status; MMS: Mini Mental Status; MNA: Mini Nutritional assessment; GI: Gastrointestinal; GU: Genitourinary; MOS: Medical outcomes study.