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. 2015 Sep 29;5:14527. doi: 10.1038/srep14527

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(A) Representative traces of spontaneous neuronal activity derived by two electrodes in the same culture during development. (B) The third week in vitro was associated with dramatic enhancement, whereas the fourth week of development was associated with overall reduction and the following stabilization of spontaneous neuronal activity. (C) The immunoreactivity of Aggrecan was markedly higher in four-week old hippocampal cultures (4W, DIV28-29, n = 30 images from 3 MEAs) as compared to three-week old cultures (3W, DIV21-22, n = 32 images from 3 MEAs). Scale bar 20 μm. *P < 0.05, **P < 0.01, ***P < 0.001; ns: non-significant (Duncan test). Data are shown as mean ± S.E.M.