Fig. 5.

Statistical comparison of genealogical trees of memory B-cell clone subtypes. Tree parameters are defined in Table S4. Whereas sole IgM and sole IgG clones are statistically significant different in their dendrogram patterns, composite clones show combinations of these patterns. The higher intraclonal diversity of mixed clones compared with sole IgM or IgG clones likely reflects that the combination of mutation patterns of IgM and of IgG members results in high values for intraclonal diversity (**P < 0.01, ***P < 0.001; paired t test, error bars show SEM).