Fig. S5.

Genealogic analysis of human memory B-cell clones. (A–I) Selected dendrograms of IgM⁺IgD⁺CD27⁺, IgM-only, and IgG⁺CD27⁺ composite clones, where the B-cell subtypes are intermingled according to their IGHV gene mutation pattern. (J–Q) Selected dendrograms of B-cell clones including class switched B cells with more than one IgG subclass. Specific subsets are indicated by a gray scale code (legend); germ-line IGHV (root) and sequential mutation events are marked as small black circles. Less than 1% of nodes/leaves represent more than one sequence; occasional contributions from independent subsets or IgG subclasses are given as split-colored circles and additional colors, respectively.