Table 1.
Gene | Conjugate | Sequence of VMO/PPMO (5′-3′) |
Control | VMO | CCTCTTACCTCAGTTACAATTTATA |
Luciferase | VMO | TCATAAACTTTCGAAGTCATGCGGC-5 |
PfPMT | VMO | AAGTTTTTAGCACCTTCATCCGTAT55 |
PfCRT | VMO | CCATTTTTGGATACTTACTTCCTTC84 |
PfDXR | PPMO | GTCCACGAGGTTCGAATCCTCTATATCC141 |
SaGyr | PPMO | ACCTTGGCCAACCA |
The boldface letters for PfDXR indicate the functional part of the sequence in the EGS. The other letters indicate the sequence needed for RNase P recognition in eukaryotic cells. The number in superscript next to the sequence indicate binding site on the transcript.