Table 1. Secreted proteins identified from 3 biological replicates of LPS-treated THP-1 cells by redox array.
| Protein | Full name | Genbank | Biol. Rep 1 | Biol Rep 2 | Biol Rep 3 | Lost with DDT |
|---|---|---|---|---|---|---|
| 4-1BB/TNFRSF91 | Tumor necrosis factor receptor superfamily, member 9 | NM_001561 | ✓ | ✓ | ||
| Aldolase A | Aldolase A | NM_000034 | ✓ | |||
| ApoD | Apolipoprotein D | NM_001647 | ✓ | ✓ | ✓ | |
| Beta Defensin 4 | Beta Defensin 4 | NM_004942 | ✓ | ✓ | ✓ | ✓ |
| Biglycan | Biglycan | NM_001711 | ✓ | ✓ | ✓ | ✓ |
| BIK | B-cell lymphocyte | NM_001197 | ✓ | ✓ | ✓ | |
| BNIP2 | BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 | NM_004330 | ✓ | ✓ | ✓ | ✓ |
| Calbindin | Calbindin | NM_004929 | ✓ | ✓ | ✓ | ✓ |
| CD79 alpha | CD79a molecule | NM_001783 | ✓ | ✓ | ✓ | ✓ |
| Contactin-1* | Contactin-1 | NM_001843 | ✓ | ✓ | ✓ | ✓ |
| Creatinine | Creatinine | N/A | ✓ | ✓ | ✓ | |
| CSH1# | Chorionic somatomammotropin hormone 1 | NM_001317 | ✓ | ✓ | ✓ | |
| CSK | Tyrosine-protein kinase CSK | NM_004383 | ✓ | ✓ | ✓ | |
| Cystatin B* | Cystatin B | NM_000100 | ✓ | ✓ | ✓ | ✓ |
| Endostatin | Endostatin; Collagen type 18 contains Endostatin | NM_030582 | ✓ | ✓ | ✓ | |
| EXTL2*,# | Exostosin-like 2 | NM_001439 | ✓ | |||
| FABP4 | Fatty acid binding protein 4 | NM_001442 | ✓ | ✓ | ✓ | ✓ |
| FOXN3 | Forkhead box N3 | NM_005197 | ✓ | ✓ | ✓ | |
| FoxO1/FKHR*,# | Forkhead box O1 | NM_002015 | ✓ | |||
| GDF1 | GDF1 (N-term) | NM_001492 | ✓ | ✓ | ✓ | |
| Ghrelin | Ghrelin | NM_016362 | ✓ | ✓ | ✓ | ✓ |
| Glypican 3 | Glypican 3 | NM_00484 | ✓ | ✓ | ✓ | ✓ |
| HP*,# | Haptoglobin | NM_005143 | ✓ | ✓ | ||
| Hepcidin | Hepcidin | NM_021175 | ✓ | ✓ | ✓ | |
| HSP70 | Heat shock protein 70 | NM_005345 | ✓ | ✓ | ✓ | ✓ |
| ICAM-2 | Intercellular Adhesion Molecule 2 | NM_000873 | ✓ | ✓ | ✓ | |
| L-1 RII* | L-1 Receptor II | NM_004633 | ✓ | ✓ | ||
| L-1 F5/FIL1delta# | Human Interleukin 1 family member 5 | NM_173170 | ✓ | ✓ | ||
| Integrin alpha V# | Integrin alpha V | NM_002210 | ✓ | ✓ | ✓ | |
| Itk# | L-2-inducible T cell kinase | NM_005546 | ✓ | ✓ | ✓ | ✓ |
| ITM2B# | Integral membrane protein 2B | NM_021999 | ✓ | ✓ | ✓ | ✓ |
| LIN41*,# | lineage41 | NM_001039111 | ✓ | |||
| Livin | Livin | NM_139317 | ✓ | ✓ | ✓ | ✓ |
| NELL2# | Neural epidermal growth factor-like 2 | NM_006159 | ✓ | ✓ | ✓ | |
| Neuropeptide Y# | Neuropeptide Y | NM_000905 | ✓ | ✓ | ||
| NRG2*,# | Pro-neuregulin-2, Neuregulin-2, Pro-NRG2 | NM_013981 | ✓ | |||
| Omentin/Intelectin | Omentin/Intelectin | NM_017625.2 | ✓ | ✓ | ✓ | ✓ |
| PTHLP*,# | Parathyroid Hormone-Like Protein | NM_198965 | ✓ | |||
| RELM alpha/RELM beta | Resistin-like alpha - Renamed RelmB in humans | NM_032579 | ✓ | ✓ | ✓ | ✓ |
| S100A10 | S100A10, ANX2LG, CAL1L, CLP11 | NM_002966 | ✓ | ✓ | ✓ | ✓ |
| S100A4 | S100 calcium-binding protein A4 | NM_002961 | ✓ | ✓ | ✓ | ✓ |
| S100A8*,# | S100 calcium-binding protein A8 | NM_002964 | ✓ | ✓ | ||
| SART1*,# | Squamous cell carcinoma antigen recognized by T-cells 1 | NM_005146 | ✓ | ✓ | ✓ | |
| SART3# | Squamous cell carcinoma antigen recognized by T-cells 3 | NM_014706 | ✓ | ✓ | ||
| SRMS# | Src-Related Kinase | NM_080823 | ✓ | ✓ | ||
| TFPI*,# | Tissue factor pathway inhibitor | NM_006287 | ✓ | ✓ | ✓ | |
| TGF-beta 5 | Transform ing growth factor-beta-5 | ✓ | ✓ | ✓ | ✓ | |
| Thrombopoietin (TPO)* | TSF TPO | NM_000460 | ✓ | |||
| TRAIL R3 (TNFRSF10C)* | TRAIL R3 (TNFRSF10C) | NM_003841 | ✓ | ✓ | ✓ | |
| TRPC1* | Transient receptor potential cation channel, subfamily C | NM_003304 | ✓ | ✓ | ||
| TXK# | Tyrosine-protein kinase TXK | NM_003328 | ✓ | ✓ | ||
| Tyk2# | Tyrosine kinase 2 | NM_003331 | ✓ | ✓ | ||
| VDUP-1 | Vitamin D3 up-regulated protein 1 | NM_006472 | ✓ | ✓ | ||
| VEGF-C*,# | VEGF-2 is the same as VEGF-C | NM_005429 | ✓ | ✓ | ||
| Vitamin D Receptor | Vitamin D Receptor | NM_000376 | ✓ | ✓ | ✓ |
*indicates proteins identified only in cell supernatants, but not in cell lysates.
#indicates proteins identified in THP-1 cell supernatants treated with LPS, but not in supernatants from untreated THP-1 cells.