Table 2.
Effect of Magnesium Sulfate on Abnormalities Detected by Neonatal Cranial Ultrasound
| All children: Term ultrasounds | Children born before 32 weeks: most severe findings in serial ultrasounds | |||||
|---|---|---|---|---|---|---|
| MgSO4 N=854 n (%) | Placebo N=922 n (%) | Adjusted OR (95% CI)* | MgSO4 N=777 n (%) | Placebo N=836 n (%) | Adjusted OR (95% CI)* | |
| Echodensity** | n/a | n/a | n/a | 10 (1.3) | 28 (3.3) | 0.38 (0.19, 0.79) |
| Echolucency | 23 (2.7) | 40 (4.3) | 0.60 (0.36, 1.02) | 26 (3.3) | 46 (5.5) | 0.59 (0.36, 0.97) |
| PVL | 10 (1.2) | 16 (1.7) | 0.67 (0.30, 1.49) | 14 (1.8) | 19 (2.3) | 0.79 (0.39, 1.59) |
| Ventriculomegaly | 26 (3.0) | 32 (3.5) | 0.81 (0.47, 1.40) | 39 (5.0) | 45 (5.4) | 0.87 (0.55, 1.37) |
| IVH (all) | 92 (10.8) | 113 (12.3) | 0.86 (0.64, 1.16) | 160 (20.6) | 181 (21.7) | 0.93 (0.73, 1.18) |
| IVH grades III/IV | 6 (0.7) | 12 (1.3) | 0.54 (0.20, 1.45) | 15 (1.9) | 27 (3.2) | 0.57 (0.30, 1.09) |
| Any of the above | 123 (14.4) | 156 (16.9) | 0.82 (0.63, 1.06) | 186 (23.9) | 217 (26.0) | 0.89 (0.71, 1.12) |
MgSO4 = magnesium sulfate; PVL = periventricular leukomalacia; IVH = intraventricular hemorrhage
*
Adjusted for correlations between twins
**
Since only three children had an echodensity detectable at the term ultrasound, these data are omitted.