Table 3.
Effect of Findings from the Term Ultrasound on Cerebral Palsy, and Mediation of the Association of MgSO4 with Cerebral Palsy
| MgSO4 | Placebo | |||||||
|---|---|---|---|---|---|---|---|---|
| Effect of Ultrasound Abnormality on the risk of CP (OR and 95% CI)* | CP (n=35) | No CP (n=819) | CP (n=65) | No CP (n=857) | Effect of MgSO4 on the risk of CP after adjusting for CUS finding (OR and 95% CI)** | % of the total effect explained by the CUS finding | p-value for effect of CUS finding† | |
| Echolucency | 17.0 (9.7, 29.5) | 7 | 16 | 20 | 20 | 0.61 (0.39, 0.94) | 16% | 0.06 |
| PVL | 70.9 (27.3, 184) | 7 | 3 | 13 | 3 | 0.56 (0.36, 0.88) | 3% | 0.33 |
| Ventriculomegaly | 9.9 (5.6, 17.6) | 4 | 22 | 15 | 17 | 0.56 (0.36, 0.87) | 2% | 0.45 |
| IVH (all) | 3.1 (1.9, 5.0) | 8 | 84 | 19 | 94 | 0.57 (0.37, 0.87) | 4% | 0.33 |
| IVH grades III/IV | 18.0 (6.8, 47.4) | 0 | 6 | 9 | 3 | 0.58 (0.38, 0.89) | 6% | 0.23 |
| Any of the above | 6.0 (4.0, 9.1) | 16 | 107 | 33 | 123 | 0.59 (0.38, 0.90) | 13% | 0.14 |
MgSO4 = magnesium sulfate; CP = cerebral palsy; PVL = periventricular leukomalacia; IVH = intraventricular hemorrhage; CUS = cranial ultrasound
*
Odds ratio (95% CI) adjusted for correlations between twins.
**
Odds ratio (95% CI) adjusted for correlations between twins. Note that without including the effect of the CUS finding, the odds ratio (95% CI) for CP of MgSO4 is 0.56 (0.37, 0.86)
†
Sobel test