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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Gynecol Oncol. 2015 Aug 1;139(1):90–96. doi: 10.1016/j.ygyno.2015.07.110

Table 2.

Statistically significant associations between tag SNP's in the Th1 pathway and cervical and vulvar cancer risk, Seattle-Puget Sound Region, 1986-2004

Gene Site Cancer type SNP Functiond Allele Age-adjusted OR (95% CI) p-value
CSF2a Vulva SCC (HPV+) rs25882 missense C/T 1.28(1.04,1.57) 0.0187**
rs27438 intergenic A/G 1.26(1.03,1.54) 0.0268**
CSF2RBa,e Cervix SCC (all subtypes) rs16997517 missense C/T 0.37(0.17,0.82) 0.0146
Cervix AC (all subtypes) rs131840 coding sequence C/T 0.79(0.63,0.97) 0.0273
rs738149 intronic A/G 0.79(0.65,0.95) 0.0131
Vulva SCC (HPV+) rs16997517 missense C/T 0.32(0.14,0.76) 0.0092
rs738149 intronic A/G 1.22(1.00,1.48) 0.0457
rs16845 missense C/G 0.64(0.42,0.98) 0.0413
IL1B Cervix AC (all subtypes) rs1071676 UTR-3 C/G 0.80(0.66,0.97) 0.0212
rs1143634 coding sequence C/T 0.81(0.67,0.98) 0.027
IL1R1-IL1RL2 Cervix SCC (all subtypes) rs3917273 intronic A/T 0.81(0.69,0.97) 0.0179
Cervix AC (all subtypes) rs7583215 intronic C/T 1.31(1.06,1.61) 0.0122
IL1R2 Cervix AC (HPV16 only) rs2072475 intronic A/G 0.57(0.36,0.90) 0.0168
rs2072476 intronic A/G 0.51(0.29,0.89) 0.0186
rs719250 intronic A/G 0.51(0.28,0.90) 0.0216
Cervix AC (all subtypes) rs2072475 intronic A/G 0.74(0.59,0.93) 0.0095
IL1RN Cervix SCC (all subtypes) rs9005 UTR-3 A/G 0.80(0.66,0.97) 0.0209
IL18 Cervix SCC (HPV16 only) rs187238 nearGene-5 C/G 0.75(0.56,1.00) 0.0486
rs1946519 nearGene-5 A/C 0.75(0.58,0.97) 0.0305
rs5744222 nearGene-5 A/C 1.32(1.01,1.72) 0.0401
IL18BP Cervix AC (HPV16 only) rs1892919 intronic C/T 1.71(1.03,2.82) 0.037
IL12Ab,f Vulva SCC (HPV+) rs2243154 intronic A/G 1.37(1.04,1.81) 0.0254
IL12Bb,f Cervix AC (all subtypes) rs10052709 intronic C/G 0.72(0.56,0.93) 0.0103
rs2569254c intronic C/T 1.23(1.01,1.50) 0.0438
rs3181225 intergenic C/T 1.26(1.04,1.53) 0.0202
rs3213119 missense G/T 0.52(0.29,0.94) 0.0294
Vulva SCC (HPV+) rs2569254c intronic C/T 1.41(1.13,1.76) 0.0024**
rs3181225 intergenic C/T 1.40(1.13,1.73) 0.0021**
rs6870828 intergenic C/T 1.23(1.03,1.47) 0.0218b
IL12RB2b,f Cervix AC (all subtypes) rs2307153 missense A/G 1.78(1.05,3.00) 0.0314
IL2RAb,g Cervix SCC (all subtypes) rs2228150 coding sequence A/G 1.91(1.22,2.99) 0.0047
rs3134883 intronic C/T 1.20(1.00,1.44) 0.0462
Cervix SCC (HPV16 only) rs2228150 coding sequence A/G 2.11(1.15,3.86) 0.0152
rs10905656 intronic A/C 0.71(0.55,0.92) 0.0106
rs12722516 intronic C/T 1.96(1.11,3.45) 0.0202
rs6602379 intronic A/G 0.71(0.54,0.94) 0.0174
rs7072398 intronic A/G 0.74(0.58,0.95) 0.0196
rs7910961 intronic C/T 0.68(0.51,0.90) 0.0066
g Cervix AC (all subtypes) rs12722588 intronic A/G 1.41(1.03,1.93) 0.033
rs1323658 intronic 0.36(0.15,0.84) 0.0185
rs2104286 intronic A/G 1.33(1.01,1.76) 0.0457
Cervix AC (HPV16 only) rs10905669 intronic C/T 1.24(1.01,1.51) 0.0351
rs12722486 intronic A/G 0.59(0.37,0.94) 0.0274
IL2RBb Cervix AC (HPV16 only) rs3218253 intronic C/T 1.34(1.01,1.77) 0.0435
IL3a Vulva SCC (HPV+) rs181781 nearGene-5 A/G 1.43(1.07,1.91) 0.0142
rs31481 intronic A/G 1.33(1.07,1.66) 0.0119
rs40401 missense C/T 1.29(1.05,1.58) 0.0133
IFNG Cervix AC (all subtypes) rs2069716 intronic A/G 0.66(0.45,0.97) 0.0368
TNFb,h Cervix SCC (all subtypes) rs1052248 nearGene-3 A/T 0.74(0.61,0.89) 0.0019**
rs1799964 nearGene-5 C/T 0.65(0.52,0.81) 0.0001**
rs2009658 nearGene-5 C/G 0.63(0.49,0.81) 0.0003**
rs2229094 missense C/T 0.66(0.54,0.81) 0.0001**
rs2239704 UTR-5 G/T 1.31(1.10,1.55) 0.0019**
rs2256965 intronic A/C/T 1.22(1.04,1.44) 0.0174
rs3093662 intronic A/G 0.69(0.48,0.98) 0.0381
rs915654 nearGene-5 A/T 0.81(0.68,0.97) 0.0192
Cervix SCC (HPV16 only) rs1052248 nearGene-3 A/T 0.70(0.53,0.93) 0.0149
rs1799964 nearGene-5 C/T 0.65(0.47,0.90) 0.0091
rs2009658 nearGene-5 C/G 0.57(0.38,0.87) 0.0085
rs2229094 missense C/T 0.61(0.45,0.83) 0.0017**
rs2239704 UTR-5 G/T 1.35(1.05,1.72) 0.0179
rs915654 nearGene-5 A/T 0.74(0.57,0.97) 0.0288
h Cervix AC (all subtypes) rs1799964 nearGene-5 C/T 0.80(0.66,0.97) 0.0261
rs2229094 missense C/T 0.80(0.67,0.96) 0.0172
rs2239704 UTR-5 G/T 1.30(1.10,1.52) 0.0016**
rs2256965 intronic A/C/T 1.20(1.03,1.41) 0.0199
rs915654 nearGene-5 A/T 0.77(0.65,0.91) 0.0019**
Cervix AC (HPV16 only) rs2256965 intronic A/C/T 1.34(1.04,1.73) 0.0241
rs915654 nearGene-5 A/T 0.75(0.57,0.99) 0.0455
h Vulva SCC (HPV+) rs1052248 nearGene-3 A/T 0.74(0.60,0.90) 0.0028**
rs1799964 nearGene-5 C/T 0.77(0.62,0.96) 0.021
rs2009658 nearGene-5 C/G 0.71(0.54,0.93) 0.0137
rs2229094 missense C/T 0.71(0.58,0.88) 0.0013**
rs2239704 UTR-5 G/T 1.58(1.33,1.88) <0.0001**
rs2256965 intronic A/C/T 1.49(1.25,1.77) <0.0001**
rs915654 nearGene-5 A/T 0.65(0.53,0.78) <0.0001**
rs1800610 intronic C/T 1.52(1.11,2.08) 0.0093
rs769178 intergenic A/C 1.65(1.20,2.26) 0.0019**
TNFRSF1Ab,h Cervix SCC (all subtypes) rs4149584 missense A/C/G/T 0.44(0.20,0.99) 0.0481
Cervix SCC (HPV16 only) rs1800693 intronic A/G 1.33(1.04,1.70) 0.0242
rs4149575 intronic A/C 0.55(0.32,0.95) 0.0322
rs767455 coding sequence C/T 1.30(1.01,1.66) 0.0386
TNFRSF1Bb Cervix AC (HPV16 only) rs1061631 UTR-3 A/G 1.50(1.11,2.03) 0.0078
rs1148458 intronic C/T 1.62(1.01,2.60) 0.0469
rs976881 intronic A/G 1.38(1.06,1.81) 0.0183
h Vulva SCC (HPV+) rs1061631 UTR-3 A/G 1.24(1.01,1.53) 0.0443
rs976881 intronic A/G 1.21(1.01,1.45) 0.0377
rs17882988 intronic A/G 1.26(1.00,1.58) 0.0466
rs499646 intronic C/T 0.62(0.39,0.97) 0.0365
rs652625 nearGene-5 A/T 0.65(0.43,0.99) 0.0463

Highlighted portions indicate previously published results from our study population; references are noted for prior reports.

**

Significant after correction for multiple testing using Holm's stepdown procedure

a

Results for squamous cell carcinoma of the cervix previously published by our group

b

Results for squamous cell carcinoma (all), adenocarconoma (all) and HPV+ vulvar cancer previously published by our group

c

rs2569254 had 6.1% genotype data

d

intronic denotes that the SNP is located in the intronic region of the gene (except in the first 2 or last 2 bases), intergenic denotes that the SNP is located in between two genes, nearGene-3 denotes the SNP is located near the 3’ end, nearGene-5 denotes the SNP is located near the 5’ end, UTR-3 denotes that the SNP is located in the untranslated 3’ region, UTR-5 denotes that the SNP is located in the untranslated 5’ region, missense denotes that the SNP is present in the coding region and causes a change in the coded peptide, and coding sequence denotes that the SNP is present in the coding region and does not cause a change in the peptide coded.

e

See reference 17 (Johnson et. al.)

f

See reference 18 (Hussain et. al.)

g

See reference 19 (Hussain et. al.)

h

See reference 16 (Bodelon et. al.)