Table 3.

Statistically significant associations between tag SNP's in the Th2 pathway and cervical and vulvar cancer risk, Seattle-Puget Sound Region, 1986-2004

Gene	Site	Cancer type	SNP	Function	Allele	Age-adjusted OR (95% CI)	p-value
IL4R	Vulva	SCC (HPV+)	rs3024668	nearGene-5	A/G	0.59(0.37,0.95)	0.0304
IL6	Cervix	SCC (all subtypes)	rs2069840	Intronic	C/G	1.25(1.05,1.49)	0.0137
	Cervix	SCC (HPV16 only)	rs2069840	Intronic	C/G	1.32(1.02,1.70)	0.0327
			rs2069837	Intronic	A/G	0.42(0.21,0.81)	0.0101
IL10a	Cervix	SCC (HPV16 only)	rs3024509	Intronic	C/T	0.49(0.26,0.93)	0.0293
	Cervix	AC (HPV16 only)	rs3024509	Intronic	C/T	0.48(0.24,0.95)	0.0337
			rs1800894	nearGene-5	A/G	0.34(0.12,0.94)	0.0376
IL10RAa,c	Cervix	AC (all subtypes)	rs2229113b	Missense	A/G	1.21(1.02,1.43)	0.0304
			rs2256111	coding sequence	A/G	1.19(1.01,1.39)	0.0326
			rs2512143	Intronic	A/G	1.23(1.05,1.45)	0.0129
			rs2512148	Intergenic	A/C	1.22(1.04,1.44)	0.0172
IL10RBa	Cervix	AC (HPV16 only)	rs2843701	Intronic	C/T	0.75(0.57,0.98)	0.0327
TGFB1	Cervix	SCC (all subtypes)	rs11466338	Intronic	A/G	1.48(1.05,2.09)	0.0243
TGFB2	Cervix	SCC (HPV16 only)	rs17047804	Intronic	C/T	1.55(1.06,2.26)	0.0237
			rs2000220	Intronic	A/G	1.29(1.01,1.65)	0.0407
	Cervix	AC (all subtypes)	rs4846476	Intronic	C/G	0.81(0.67,0.99)	0.0396
TGFB3	Cervix	SCC (all subtypes)	rs3917148	Intronic	A/C	1.36(1.00,1.85)	0.0494
	Vulva	SCC (HPV+)	rs3917200	Intronic	C/T	1.44(1.03,2.01)	0.0347
TGFBR1	Cervix	SCC (all subtypes)	rs10512263	Intronic	C/T	0.66(0.46,0.94)	0.0226
	Cervix	SCC (HPV16 only)	rs10512263	Intronic	C/T	0.51(0.29,0.91)	0.0236
TGFBR2	Cervix	AC (HPV16 only)	rs9858487	Intronic	C/G	1.69(1.00,2.83)	0.0481
	Vulva	SCC (HPV+)	rs3087465	nearGene-5	A/G	1.23(1.00,1.51)	0.0451

Highlighted portions indicate previously published results from our study population.

^aResults for squamous cell carcinoma (all), adenocarconoma (all) and HPV+ vulvar cancer previously published by our group

^brs2229113 had 5.1% missing genotype data

^cSee reference 18 (Hussain et. al.)