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. 2015 Apr 22;14(7):1814–1830. doi: 10.1074/mcp.M114.041335

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© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

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Fig. 2. — Heatmap of expression patterns of proteins and transcripts in connection with tumor grade, lymph node status, ER and HER2 status. Genes marked with full green dots were up-regulated whereas those marked with empty green dots were down-regulated at protein level in G1 N1–2 versus G1 N0 tumors. Genes marked with full orange dots were statistically significantly up-regulated at transcript level in G1 N1–2 versus G1 N0 tumors (no down-regulated transcripts were found here). The genes up-regulated at both levels are considered as core genes of G1 metastasis related clusters 1 (CPB1, PDLIM2, RNF25, associated with lymph node metastasis of grade 1 tumors and had low levels in grade 3 tumors), G1 metastasis related clusters 2 (STMN1, TMSB10 associated with lymph node metastasis of grade 1 tumors and had high levels in grade 3 tumors) and G1 metastasis related clusters 3 (RELA, YWHAH associated with lymph node metastasis of grade 1 tumors with no significant difference between low and high grade tumors). Clusters related to estrogen receptor (ESR1) and HER2 receptor, and PLAU+SERPINE1 genes are also highlighted.