Table II. Cx43-interacting proteins (represented as gene name) from chondrocytes of healthy donors using the Cx43 IP-based proteomic approach. The values of peptide probability\score, sequence coverage and number of peptides found are shown in supplementary Fig. S1. Only proteins that show >95% confidence and score >1.3 were considered for this study.

Group\Complex	Gene name
Nucleosome. Histones	HIST1H1T, HIST1H2AC, H2AFJ, HIST2H2BF, H3F3A, HIST1H4A
Transcription related factors	PTRF, NCL, CAND1, SND1, STAT1, RAN
RNA-binding proteins	MVP*, HNRNPA1*, HNRNPA2*, HNRNPA3, HNRNPK, NLC, RAN*, PTRF
RNA transport*
RNA splicing	HNRNPA1, HNRNPA2, HNRNPA3, HNRNPK, SNRPD3
Ribosome	RPS16, RPS18, RPS19, RPS24, RPS26, RPS4X, RPS5, RPS7, RPS8, RPS9, RPLP2, RPL11, RPL12, RPL15, RPL17, RPL21, RPL24, RPL26, RPL27A, RPL3, RPL35, RPL35A, RPL36, RPL4, RPL6, RPL7, RPL7A
Translation	EEF2, EEF1AL3, EEF1G, EIF5AL1
Endomembrane system (transport within the cell)	KPNB1#, RAN#, LMNA, MVP#
Nuclear Pore Complex#
Mitochondrial	SOD2, ATP5J2
Antioxidant activity	PRDX1, SOD2
Generation of precursor metabolites and energy	PKM2, ENO1, GAPDH, LDHA, ALDOA, PYGB, PGK1, SOD2
Protein folding and other-related proteins	CRYAB, HSPA8, HSP90AB1, HSP90B1, PPIB, PPIA, HSPA5, P4HB, PDIA3, HSPB1, SERPINH1