Table IV. Cx43-interacting proteins exclusively identified in samples from healthy, early OA and moderate OA patients. The table represents some of the Cx43-interacting proteins that were exclusively identified for each group. For the complete list of interactors, see supplementary Table S4. The values of peptide probability\score, sequence coverage and number of peptides found are shown in supplementary figures. Only proteins that show >95% confidence and score >1.3 were considered for this study.

	Protein name	Gene name	Score	Cov.	No. pept.
Healthy	ATP synthase subunit f, mitochondrial	ATP5J2	2	13.8	1
	Erzin	EZR	2	3.9	1
	Protein S100-A10	S100A10	2	14.4	1
	Protein S100-A11	S100A11	2	10.5	1
	Protein S100-A6	S100A6	2	16.7	1
	Ras-related protein Rap-1A	RAP1A	2	7.6	1
	Superoxide dismutase [Mn], mitochondrial	SOD2	2	15.3	1
	Thy-1 membrane glycoprotein	THY1	4	24.2	2
	Transforming protein RhoA	RHOA	2	17.6	1
	Ubiquitin-40S ribosomal protein S27a	RPS27A	2.3	24.4	1
	Vesicle-trafficking protein SEC22b	SEC22B	2	18.1	1
Early OA (grade I)	14–3-3 protein zeta\delta	YWHAZ	4	28.2	2
	1,4-alpha-glucan-branching enzyme	GBE1	2	13	1
	Myosin-10	MYH10	11.36	46.5	7
	Protein piccolo	PCLO	1.81	19.2	1
	Coatomer subunit alpha	COPA	2	28.8	1
	Destrin	DSTN	2.14	44.2	1
	Integrin alpha-V	ITGAV	2.03	20.9	1
	Matrin-3	MATR3	2.05	27.4	1
	Septin-2	SEPT2	2	21.3	1
	Transforming growth factor-beta-induced protein ig-h3	TGFBI	2.32	19.8	1
	Vigilin	HDLBP	3.84	34.6	2
Moderate OA (grade III)	26S proteasome non-ATPase regulatory subunit 2	PSMD2	2	7.3	1
	A-Kinase anchor protein 2	AKAP2	2	24.7	1
	AP-2 complex subunit alpha-1	AP2A1	2.82	16	2
	ATP-citrate synthase	ACLY	3.96	18.1	2
	Coatomer subunit beta and gamma	COPB1	2.03	16.8	1
		COPG	6.47	24.5	4
	Heterochromatin protein 1-binding protein 3	HP1BP3	2	17.9	2
	High mobility group protein B1	HMGB1	1.73	23.7	2
	LIM domain and actin-binding protein 1	LIMA1	3.07	28.7	2
	LIM domain only protein 7	LMO7	2.53	25.9	2
	Stress-70 protein, mitochondrial	HSPA9	5.26	31.1	3
	Transgelin	TAGLN	1.39	42.3	1
	Zyxin	ZYX	2.01	14.3	1