Table 2.
Population Characteristics | CF-Ca(n=226) | N-CFb(n=57) | p valueg |
---|---|---|---|
| |||
Age at last follow up, mean (SD), months | 49 (14) | 52 (12) | 0.18 |
| |||
Female gender, n (%) | 97 (43) | 31 (54) | 0.14 |
| |||
Race/ethnicity, n (%) | 0.036c | ||
Whites | 108 (47.8) | 22 (38.6) | |
Hispanics | 90 (39.8) | 32 (56.1) | |
Non-Hispanics Blacks | 12 (5.3) | 0 (0.0) | |
Multiple and others | 15 (6.6) | 3 (5.3) | |
Missing | 1(0.4) | 0 (0.0) | |
| |||
Birth weight, mean (SD), kg | 3.11 (0.59) n=225 |
3.39 (0.53) n=56 |
0.004 |
| |||
IRT median (IQR)d, ng/mL | 162 (110-241) | 75 (70-96) | <0.0001 |
| |||
Meconium Ileus, n (%) | 36 (16) | 0 (0.0) | 0.0002 |
Highest Sweat Chloride, median (range), mmol/L | 95 (25-135) | 18 (7-52) | <0.0001 |
Sweat Chloride ≥ 60 mmol/L, n (%) | 184 (89%) n=207 |
0 (0.0) n=56 |
|
| |||
Pancreatic Insufficiency, n (%) | 180/220 (81.8) | 1/57 (1.8) | <0.0001 |
| |||
P. aeruginosa acquisition in the first year of life, probability ± s.e. | 0.18 ± 0.03 | 0.16 ± 0.06 | 0.54 |
| |||
P. aeruginosa Colonization, n (%) | n/ae | ||
Unknown | 39 (17.3) | 40 (70.2) | |
Never | 84 (37.2) | 8 (4.0) | |
Yes-but not persistent | 52 (23.0) | 6 (0.5) | |
Persistent | 51 (22.6) | 3 (5.3) | |
| |||
Lost to follow up, n (%) | 41 (18.1) | 31 (54.4) | <0.0001 |
| |||
Deaths, n (%) | 6 (2.6)f | 0 (0.0) | 0.21 |
Two CF-causing variants (Two from the 40-panel or one from the panel and one sequenced)
- a,bDenominators are the total of subjects per group unless otherwise specified
Hispanics compared to all other race/ethnicities.
IRT=Immunoreactive Trypsinogen, IQR=Interquartile Range.
Statistical comparison is inappropriate due to a large percentage of missing data in the N-CF group.
The causes of death were: complications from prematurity including one confirmed case of acute respiratory distress syndrome (n=3), complications from Biotinidase deficiency (n=1), sepsis post-intestinal perforation repair (n=1), and acute respiratory failure secondary to CF-related pneumonia and liver disease (n=1).
p values after adjusting for Hispanic versus all others are as follows: birth weight 0.001, IRT <0.0001, meconium ileus 0.0017, sweat chloride <0.0001, pancreatic insufficiency <0.0001, P. aeruginosa acquisition 0.56, lost to follow up <0.0001, death 0.23.