Table 2.

Selected characteristics of two study groups

Population Characteristics	CF-Ca(n=226)	N-CFb(n=57)	p valueg
Age at last follow up, mean (SD), months	49 (14)	52 (12)	0.18
Female gender, n (%)	97 (43)	31 (54)	0.14
Race/ethnicity, n (%)			0.036c
Whites	108 (47.8)	22 (38.6)
Hispanics	90 (39.8)	32 (56.1)
Non-Hispanics Blacks	12 (5.3)	0 (0.0)
Multiple and others	15 (6.6)	3 (5.3)
Missing	1(0.4)	0 (0.0)
Birth weight, mean (SD), kg	3.11 (0.59) n=225	3.39 (0.53) n=56	0.004
IRT median (IQR)d, ng/mL	162 (110-241)	75 (70-96)	<0.0001
Meconium Ileus, n (%)	36 (16)	0 (0.0)	0.0002
Highest Sweat Chloride, median (range), mmol/L	95 (25-135)	18 (7-52)	<0.0001
Sweat Chloride ≥ 60 mmol/L, n (%)	184 (89%) n=207	0 (0.0) n=56
Pancreatic Insufficiency, n (%)	180/220 (81.8)	1/57 (1.8)	<0.0001
P. aeruginosa acquisition in the first year of life, probability ± s.e.	0.18 ± 0.03	0.16 ± 0.06	0.54
P. aeruginosa Colonization, n (%)			n/ae
Unknown	39 (17.3)	40 (70.2)
Never	84 (37.2)	8 (4.0)
Yes-but not persistent	52 (23.0)	6 (0.5)
Persistent	51 (22.6)	3 (5.3)
Lost to follow up, n (%)	41 (18.1)	31 (54.4)	<0.0001
Deaths, n (%)	6 (2.6)f	0 (0.0)	0.21

^aTwo CF-causing variants (Two from the 40-panel or one from the panel and one sequenced)

^b

One panel and one or more non CF-causing variants identified by sequencing

• ^a,bDenominators are the total of subjects per group unless otherwise specified

^cHispanics compared to all other race/ethnicities.

^dIRT=Immunoreactive Trypsinogen, IQR=Interquartile Range.

^eStatistical comparison is inappropriate due to a large percentage of missing data in the N-CF group.

^fThe causes of death were: complications from prematurity including one confirmed case of acute respiratory distress syndrome (n=3), complications from Biotinidase deficiency (n=1), sepsis post-intestinal perforation repair (n=1), and acute respiratory failure secondary to CF-related pneumonia and liver disease (n=1).

^gp values after adjusting for Hispanic versus all others are as follows: birth weight 0.001, IRT <0.0001, meconium ileus 0.0017, sweat chloride <0.0001, pancreatic insufficiency <0.0001, P. aeruginosa acquisition 0.56, lost to follow up <0.0001, death 0.23.