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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Immunol Rev. 2015 Sep;267(1):259–282. doi: 10.1111/imr.12326

Figure 3. HLA-C allotypes differ in their level of expression at cell surfaces.

Figure 3

HLA-C expression level as predicted from polymorphism in the mi-RNA-148 binding site sequence. Allotypes are first grouped according to the presence of the C1 or C2 epitope and then by higher expression, for HLA-C alleles having a nucleotide deletion in the mi-RNA-148 binding site, and lower expression for HLA-C alleles with an intact binding site (37). Expression levels of allotypes in grey-shaded boxes were investigated by Kulkarni et al (36) and conform to these groupings. Analysis by Apps et al (139) gave a hierarchy of cell surface expression that has some differences from the predictions based on the mi-RNA-148 binding site polymorphism. The hierarchy of expression of the C1 containing allotypes was *14>*01>*12>*16>*08>*03>*07 and for the C2 allotypes *18>*06>*15>*04>*02>*05>*17 (139).