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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Immunol Rev. 2015 Sep;267(1):259–282. doi: 10.1111/imr.12326

Figure 4. Polymorphism and functional variation of human KIR.

Figure 4

Listed for each KIR are the number of allotypes currently defined (http://www.ebi.ac.uk/ipd/kir/) (2), the signaling function of the KIR, its HLA class I ligand, and the phylogenetic lineage to which it belongs. KIR2DL2 and KIR2DL3 are encoded by alleles of the same gene (KIR2DL2/3) but are listed separately because of their functional differences and sequence divergence. Likewise for KIR3DL1 and KIR3DS1, which are both encoded by alleles of the KIR3DL1/S1 gene. ? denotes uncertainty.