. Author manuscript; available in PMC: 2015 Sep 29.

Published in final edited form as: Int J Cancer Oncol. 2015 Jun 2;2(2):215. doi: 10.15436/2377-0902.15.017

Table 1.

	Effect on hTERT	Expression/Activity in HTLV cells	Known HTLV Activators/Repressors	Tested Effect(s) on hTERT promoter
c-myc	+	+	Tax (+)	Tax increases c-myc binding to hTERT promoter
SP1	+	−	−	Tax increases SP1 binding to hTERT promoter HBZ/JunD heterodimers interact with SP1 on hTERT promoter
USF	+		Tax (+)	USF binding to hTERT promoter not affected in Tax-expressing cells.
STAT3	+	+	−	Unknown (IL-2 signaling increases hTERT expression in HTLV cells)
PI3K	+	+	Tax (+)	Tax/IL-2-expression increase activity
NFAT	+	+	p12(I)	Unknown
Mad	−	UN	−	Max binding to hTERT promoter not affected in HTLV-/Tax-expressing cells; c-myc/Max may replace Mad1/Max on promoter
HDACs	−	−	HBZ (−)
E2F1	−	+	Tax (+)	Unknown
TAK1	−	UN	Tax (+)	Unknown
p53	−	+(inactive)	Tax (−)	p53 binding to hTERT promoter not affected in HTLV-/Tax-expressing cells
Smad3	−	+	Tax (−) HBZ (+)	Unknown
Menin	−	+	HBZ (−)	HBZ/JunD/menin/p300 complex relieves JunD/menin inhibition of hTERT promoter
Tal1	−	UN	Tax (+) HBZ (−)	Tal1 decreases hTERT mRNA/HBZ promotes proteosomal degradation of Tal1.