Table 2.
| Effect on hTERT | Expression/Activity in HTLV cells | Known HTLV Activators/Repressors | Tested Effect(s) on hTERT promoter | |
|---|---|---|---|---|
| AKT | + (phosphorylates/Expression) |
+ | Tax (+) | The PI3K/AKT pathway was shown to positively influence telomerase activity in HTLV-I cells; unknown direct effects. |
| NFκB (p65) | + (Localization/Expression) |
+ | Tax (+)HBZ (−) | NF-κB mediated SP1 and c-myc activation of hTERT promoter; unknown direct effects. |
| PKC | + (phosphorylates/Expression) |
+ | Tax (+) | Unknown |
| 14-3-3 | + (Localization) |
UN | UN | Unknown |
| SHP2 | + (Localization) |
+/UN | UN | Unknown |
| Abl | − (phosphorylates) |
UN | UN | Unknown |
| PPA | − (De-phosphorylates) |
UN | Tax (−) | Not tested; Inhibition of PPA leads to loss of cell viability in HTLV-I cells. |