Table 2. Hazard ratios (95% CIs) for association between gallstone disease and incident ischemic heart disease.

	Total		Men		Women
	Without GSD	With GSD	Without GSD	With GSD	Without GSD	With GSD
Case/person-years	23,017/3,233,478	1,942/197,646	9,772/1,337,533	473/50,998	13,245/1,895,946	1,469/146,648
Model 1	1.00	1.26 (1.21–1.32)	1.00	1.15 (1.05–1.26)	1.00	1.29 (1.23–1.37)
Model 2	1.00	1.24 (1.18–1.30)	1.00	1.12 (1.02–1.23)	1.00	1.28 (1.22–1.36)
Model 3	1.00	1.23 (1.17–1.28)	1.00	1.11 (1.02–1.22)	1.00	1.27 (1.20–1.34)
Sensitivity analyses
Model 4	1.00	1.22 (1.17–1.28)	1.00	1.11 (1.01–1.22)	1.00	1.26 (1.20–1.34)
Model 5	1.00	1.22 (1.16–1.28)	1.00	1.11 (1.01–1.21)	1.00	1.26 (1.20–1.34)
Model 6	1.00	1.23 (1.17–1.29)	1.00	1.12 (1.01–1.24)	1.00	1.27 (1.20–1.35)

CIs denotes confidence intervals; GSD, gallstone disease. Model 1 were adjusted for age. Model 2 additionally included sex (for whole cohort only), level of education, marital status, alcohol consumption, smoking status, physical activity, intake frequencies of red meat, fresh fruits, and vegetables, prevalent hypertension, prevalent diabetes, family history of heart attack, menopausal status (for women only). Model 3 additionally included body mass index (BMI). On the basis of model 3, model 4 additionally included the histories of digestive system diseases including chronic hepatitis/cirrhosis and peptic ulcer; model 5 replaced BMI with WC; model 6 excluded diabetic patients from the analyses.