Table 3. Hazard ratios (95% CIs) for association between gallstone disease and incident ischemic heart disease according to the duration (years) since the first diagnosis.

Duration	Without GSD		With GSD
	Case/person-years	HR	Case/person-years	HR (95% CI)
Total	23,017/3,233,478
0–		1.00	523/54,333	1.22 (1.12–1.34)
3–		1.00	696/73,867	1.21 (1.13–1.31)
10–		1.00	723/69,235	1.25 (1.16–1.34)
Men	9,772/1,337,533
0–		1.00	142/15,293	1.16 (0.98–1.37)
3–		1.00	184/19,358	1.20 (1.04–1.39)
10–		1.00	147/16,325	0.99 (0.84–1.16)
Women	13,245/1,895,946
0–		1.00	381/39,041	1.24 (1.12–1.38)
3–		1.00	512/54,510	1.22 (1.12–1.33)
10–		1.00	576/52,910	1.35 (1.24–1.46)

CIs denotes confidence intervals; GSD, gallstone disease. The multivariate models were adjusted for the following baseline factors: age, sex (for whole cohort only), level of education, marital status, alcohol consumption, smoking status, level of physical activity, intake frequencies of red meat, fresh fruits, and vegetables, prevalent hypertension, prevalent diabetes, family history of heart attack, menopausal status (for women only), and body-mass index.