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. Author manuscript; available in PMC: 2016 Feb 6.
Published in final edited form as: Nature. 2015 Jul 1;524(7563):88–92. doi: 10.1038/nature14600

Figure 3. Input–output relationship of LC-NE neurons revealed by TRIO and cTRIO.

Figure 3

a, Schematic of CAV injections into LC output regions for TRIO and cTRIO. OB, olfactory bulb; AC, auditory cortex; Hi, hippocampus; Cb, cerebellum; Me, medulla. b, Average fractional inputs in Dbh-Cre-based input tracing (gray, n=9), TRIO (Hi, purple; OB, red; AC, blue; n=4 each), and cTRIO (Cb, green; Me, orange; n=4 each). Input neurons were grouped into 16 broader categories. Magnified insets highlight the average fraction of input from striatum-like amygdala (>98% from the central amygdala) (b′) or from Purkinje cells (b″) to LC-NE neurons that project to the 5 output regions or in Dbh-Cre-based input tracing. Error bars, s.e.m.

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