Table 1.
DNA-processing enzymes containing 4Fe-4S clusters
| Enzymea | Kingdomb | Enzymatic Activity | Referencesd |
|---|---|---|---|
| MutY, EndoIII, UDG | A, B, E | glycosylase, BER | (42,44–46,82) |
| AddAB | B | helicase-nuclease, RRc | (69,83) |
| Dna2 | A, E | helicase-nuclease, replication, RR | (73,83) |
| Exonuclease V | E | 5′-exonuclease, replication and repair | (84) |
| Primase | A, E | RNA polymerase, replication | (75,76) |
| RNA polymerase | A, E | RNA polymerase, transcription | (77,78,85) |
| Rad3/XPD | A, E | helicase, NER transcription | (59–63) |
| FancJ, ChlR1, DOG-1, RTEL | E | helicases, multiple pathways | (60,61,72) |
| DinG | B | helicase, R-loop maturation | (66) |
| DNA polymerases α, δ, ε | E | DNA polymerase, replication | (70,86) |
a
This list is not comprehensive, but represents a sampling of the many enzymes found recently to contain 4Fe-4S clusters.60,61,71,72
b
For kingdoms B = bacteria, A = archaea, E = eukarya
c
RR = recombination repair
d
References include predictions, spectroscopic, or crystallographic evidence for the presence of the 4Fe-4S clusters.