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. 2015 Sep 28;8:484. doi: 10.1186/s13104-015-1405-4

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© Michaelis et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Effects of ABCG2 depletion on UKF-NB-3^ABCG2 cell sensitivity to tozasertib and the cytotoxic ABCG2 substrate mitoxantrone. Concentrations that reduce cell viability by 50 % after 120 h incubation (IC₅₀) were determined by MTT assay in UKF-NB-3 cells, UKF-NB-3 cells transduced with a control vector (UKF-NB-3^iG2), UKF-NB-3 cells transduced with the lentiviral vector LeGO-iG2-ABCG2 encoding for ABCG2 (UKF-NB-3^ABCG2), and UKF-NB-3^ABCG2 cells in which ABCG2 was depleted using a lentiviral vector encoding an shRNA directed against the mRNA of eGFP and ABCG2 (LeGO-X-GFP2) of the LeGO-iG2-ABCG2 vector (UKF-NB-3^ABCG2-XGFP2). *P < 0.05 relative to UKF-NB-3