Fig. 5.
E2F1 deficiency affects blood coagulation in response to systemic LPS. B6;129E2F1−/− mice have elevated prothrombin time (PT; A) and activated partial thromboplastin time (aPTT; B), as well as the amount of fibrin split product (C) in the blood 18 h following systemic LPS challenge (n = 8 in each group). P values were calculated using the Mann-Whitney U-test. No differences in PT, aPTT, and fibrin split product were observed in the two strains of mice in response to saline treatment (data not shown).