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VPC01091 and FTY720 treatment attenuates pulmonary vascular permeability after IR. Mice were pretreated with vehicle, VPC01091, or FTY720 30 min before sham surgery or ischemia. Vascular permeability was assessed after 2 h of reperfusion by measuring Evans blue dye content in the lung (μg/g lung tissue) as described in materials and methods. Results are presented as means ± SE. *P < 0.05 vs. vehicle sham, #P < 0.05 vs. vehicle IR, n = 5/group.
