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. 2015 Apr 24;308(12):L1245–L1252. doi: 10.1152/ajplung.00302.2014

Fig. 4.

Fig. 4.

Neutrophil infiltration and activation after IR is significantly decreased by VPC01091 or FTY720 treatment compared with vehicle-treated mice. A: representative immunostaining of neutrophils (pink staining) within indicated groups; ×40 magnification. B: quantification of neutrophils per high-powered field (HPF) for each group. C: myeloperoxidase (MPO) levels in bronchoalveolar lavage fluid after IR were significantly reduced by VPC01091 and FTY720 treatment vs. vehicle treatment. No significant differences in neutrophil counts or MPO levels between vehicle, VPC01091, and FTY720 treatment of sham animals were observed (data not shown). Results are presented as means ± SE. *P < 0.05 vs. vehicle sham; #P < 0.05 vs. vehicle IR, n = 3–6/group.