Fig. 6.
Schematic illustrating the central mechanisms within the SFO that may mediate ANG II-dependent hypertension. ANG II, via AT1aR, induces ER stress and NADPH oxidase-dependent reactive oxygen species (ROS) production in the SFO. ER stress and oxidant signaling lead to activation of NF-κB, subsequent changes in gene expression, and downstream stimulation of sympathoexcitatory circuits. MnPO, median preoptic nucleus; OVLT, organum vasculosum lamina terminalis; SON, supraoptic nucleus; PVN, paraventricular nucleus; PP, posterior pituitary; RVLM, rostral ventral lateral medulla; CVLM, caudal ventral lateral medulla; NTS, nucleus tractus solitarii; AP, area postrema; IML, intermediolateral column of the spinal cord.