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Reduced cAMP content and signaling in liver of L-p65-KO mice. Livers were collected from mice on HFD for 16 weeks. A: pCREB. The phosphorylation was determined through Western blotting. B: cAMP levels in liver tissue. C: PDE3B protein in liver tissue. D: PDE3B mRNA expression in liver of HFD-fed mice (n = 5). Data are mean ± SEM. **P < 0.01.
