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. 2015 Jun 24;64(10):3573–3587. doi: 10.2337/db14-1107

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© 2015 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.

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OGT and OGA distribution profile in human and rat control and diabetic hearts. A: Human donor and diabetic myocardium cryosections were immunostained for α-actinin (green), OGT (magenta), and OGA (red). Regions of interest (white square and line) were chosen to plot OGT, OGA, and α-actinin signals. Signals from donor or diabetic myocardium are displayed as double y-axis graphs to illustrate the inversed distribution profile of OGT/α-actinin and OGA/α-actinin, respectively. B: Rat control and diabetic skinned myocytes were isolated from flash-frozen myocardium, fixed in 4% ultrapure formaldehyde, and immunostained as above. Regions of interest and OGT, OGA, and α-actinin signals were plotted as above and confirmed the abnormal distribution profile of OGT and OGA in diabetic hearts.