Table 1.

eMS that potentially mediate the relationship between BMI and cholesterol network gene expression

eMS		BMI-methylation				BMI-gene expression
							Indirect		Direct
CpG ID	CpG location	β	SE	P value	FDR	Gene	β	P value	β	P value
cg06500161	Body (ABCG1)	0.005	0.001	2.8E-07	5.4E-04	ABCG1	−0.005	2.6E-06	−0.025	3.7E-12
cg05323251	Body (ICAM3)	0.003	0.001	3.0E-06	2.9E-03	LDLR	0.001	2.4E-03	0.012	1.5E-07
cg10192877	Body (ABCG1)	0.004	0.001	5.3E-05	0.02	ABCG1	−0.002	1.1E-03	−0.025	3.6E-14
cg05119988	5′UTR (SC4MOL)	−0.006	0.001	1.0E-04	0.03	SC4MOL	0.001	1.2E-03	0.009	1.2E-06

Effects of BMI on methylation of cyan module gene eMS (β, SE, P value, and genome-wide FDR) and the indirect (mediated) and direct effects (β, P value) of BMI on gene expression. Indirect effects were estimated using SEM for methylation mediating the effect of BMI on gene expression (log₂ fold change of expression per 1-unit increase in BMI [kg/m²]). Some eMS were located within gene bodies (gene containing CpG in parentheses) or in the 5′ untranslated regions (UTR) of genes. Analyses included 1,264 CD14⁺ monocyte samples and were adjusted for age, sex, race, study site, and residual sample contamination with nonmonocytes.