Skip to main content
. 2015 Jul 7;64(10):3499–3509. doi: 10.2337/db15-0153

Figure 6.

Figure 6

CACs are progenitors of endocrine and ductal cell types. A–C: 4OHT injection labels 75% of Notch-responsive cells (green) with nuc-mCherry (red nuclei) in LT; Tp1:GFP fish. D–F: LT; ins:NTR regenerating islets at MTZ +7 days. nuc-mCherry labels insulin-expressing CAC progeny (yellow arrowheads). G–I: LT; Ptf1a:gfp fish at PPx +7 days. nuc-mCherry (red nuclei) labels regenerating duct, CACs (yellow asterisks), and insulin-expressing islet cells (white) but not eGFP-positive acinar cells (green). Anti-insulin (white), anti-glucagon (green in B), anti-mCherry (red), DAPI (blue). Scale bars = 25 μm.