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. 2015 Jul 7;64(10):3499–3509. doi: 10.2337/db15-0153

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© 2015 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.

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Cftr plays an important role in the pancreas. A–F: Five dpf cftr^−/− pancreata have fewer CACs (anti-Nkx6.1, green) (A–C), and secondary islet cells induced by DAPT treatment (anti-insulin plus anti-glucagon plus anti-somatostatin, arrows, red) (D–F) compared with cftr^+/− and wild-type pancreata. Scale bar = 100 μm. G–I: Quantification of the number (#) of CACs (G), surface area (H), and number of induced secondary islet cells (I) in wild-type, cftr^+/−, and cftr^−/− 5 dpf pancreata. N, number of pancreata quantified. **P < 0.05. ***P < 0.001, t test.