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. 2015 Sep 28;10(9):e0138810. doi: 10.1371/journal.pone.0138810

Fig 3. Venn diagram and outlier gene expression profile for pancreatic cancer data.

Fig 3

(a) Venn diagram of the DE genes estimated by all four methods (ANOVA, LIMMA, KW and Proposed) based on pairwise comparisons of CTC vs T, CTC vs P, CTC vs G, T vs P, T vs G and G vs P. (b) Frequency distributions of β-weights for each expression of the 8152 genes in 24 samples. (c) Scatter plot of the smallest β-weight for each of the 8152 genes vs. the gene index, where the smallest value represents the minimum value of 24 β-weights from 24 samples for each gene. The red circles between the two gray lines represent moderate/noisy outliers, whereas the other red circles, corresponding to β-weights of less than 0.2, represent extreme outliers. (d) Plot of ordered smallest β-weights in (c) for 8152 genes. (e) The 80 DE genes detected by the proposed method only, as shown in (a). Seventeen out of 80 DE genes were detected as extreme outlying genes using the β-weight function. The results for the T, P, G and CTC groups are plotted above the lines with four different colors. The outlying samples are indicated by circles above them.