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. 2015 Feb 2;26(10):2588–2598. doi: 10.1681/ASN.2014040404

Figure 5.

Figure 5.

B cells from tolerant recipients regulate IL-21–producing T cells levels and IL-21 production by T cells. (A) Dot plot of the secretion of IL-21 by activated CD4+CD25− T cells at day 3 of coculture with stimulated B cells. (B) Percentage of IL-21+ T cells at day 3 of activation and coculture with or without stimulated B cells in HVs (n=10), TOLs (n=12), and STAs (n=14) (*P<0.05; **P<0.01). (C) Concentration of IL-21 (pg/ml) in supernatants after 3 days of coculture, T cell coculture with B cells (mean±SEM; *P<0.05). (D) Percentage of GzmB+ B cells normalized on B cells plus T cells alone after increasing doses of IL-21 blocking molecule is added to coculture (0, 2, 4, 6, and 8 μg/ml) (*P<0.05; ***P<0.01).