Figure 6.

ADR-treated EC-SOD KO mice have increased pathologic β-catenin activation compared with WT mice. (A) Immunohistochemistry for β-catenin protein (red staining) in kidney sections shows increased levels in KO compared with WT mice. (B) Western blot for β-catenin. (C) Quantitative data for B, normalized to actin as a loading control. (D) Quantitative real-time RT-PCR analyses of renal matrix metalloproteinase-7 (MMP-7) mRNA expression in WT and KO mice. *P<0.05 compared with the WT group.