Table 1.
Baseline characteristics by quartiles of urine PIIINP in 958 randomly selected subcohort participants in the CHS
| Characteristic | Urine PIIINP Quartiles | |||
|---|---|---|---|---|
| 1 | 2 | 3 | 4 | |
| Range (μg/L) | ≤1.39 | >1.39–2.58 | >2.58–4.22 | >4.22 |
| n | 240 | 239 | 240 | 239 |
| Demographics | ||||
| Age±SD, y | 78±5 | 78±5 | 78±5 | 79±5 |
| Male, n (%) | 60 (25.0) | 81 (33.9) | 92 (38.3) | 145 (60.7) |
| Black, n (%) | 29 (12.1) | 27 (11.3) | 41 (17.1) | 49 (20.5) |
| Education (>high school), n (%) | 83 (34.6) | 98 (41.0) | 81 (33.8) | 90 (37.7) |
| Lifestyle factors | ||||
| Current smoking, n (%) | 18 (7.5) | 12 (5.0) | 23 (9.6) | 19 (7.9) |
| Alcohol (≥7 drinks/wk), n (%) | 28 (11.7) | 37 (15.5) | 34 (14.2) | 20 (8.5) |
| Prevalent CVD | ||||
| History of MI, n (%) | 29 (12.1) | 31 (13.0) | 23 (9.6) | 36 (15.1) |
| History of HF, n (%) | 23 (9.6) | 24 (10.0) | 13 (5.4) | 26 (10.9) |
| History of stroke, n (%) | 11 (4.6) | 15 (6.3) | 7 (2.9) | 32 (13.4) |
| Cardiovascular risk factors | ||||
| BMI±SD (kg/m2) | 26.1±4.4 | 26.6±4.8 | 27.6±5.0 | 27.2±4.6 |
| SBP±SD (mmHg) | 137.6±21.1 | 137.6±22.3 | 136.0±20.3 | 136.1±19.7 |
| DBP±SD (mmHg) | 69.2±10.0 | 69.8±12.4 | 69.3±10.8 | 70.4±11.4 |
| BP medication use, n (%) | 128 (53.3) | 141 (59.0) | 136 (56.7) | 126 (52.7) |
| Diabetes, n (%) | 20 (8.3) | 23 (9.6) | 39 (16.3) | 51 (21.5) |
| Total Chol.±SD (mg/dl) | 204.6±36.6 | 198.6±38.8 | 205.9±37.6 | 196.5±41.7 |
| Lipid medication use, n (%) | 32 (13.3) | 30 (12.6) | 27 (11.3) | 26 (10.9) |
| CRP (mg/L), median (IQR) | 2.3 (1.0–5.1) | 1.9 (0.9–3.9) | 2.7 (1.1–5.4) | 2.5 (1.3–6.4) |
| Plasma PIIINP±SD (μg/L) | 4.4±1.4 | 4.7±1.6 | 4.8±1.4 | 5.2±1.9 |
| Kidney function measures | ||||
| Baseline eGFR±SD (ml/min per 1.73 m2) | ||||
| In all participants (n=958) | 67.2±16.0 | 65.3±17.7 | 63.0±18.3 | 58.5±20.4 |
| In those with follow-up eGFR data (n=289) | 69.7±15.3 | 69.0±17.0 | 65.8±16.6 | 68.7±19.4 |
| Follow-up eGFR±SD (ml/min per 1.73 m2) (n=289) | 64.6±18.5 | 60.4±20.4 | 58.5±20.6 | 59.3±22.5 |
| Urine ACR, mg/g (IQR) | 6.4 (3.9–13.6) | 8.0 (4.7–16.6) | 7.5 (4.7–18.2) | 12.3 (7.0–52.6) |
BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; BP, blood pressure; Chol., cholesterol; CRP, C-reactive protein; IQR, interquartile range.