Table 4.
Association of urine PIIINP concentrations with risk of ESRD in participants in the CHS
| Urine PIIINP Quartiles | Urine PIIINP Continuous (Per Doubling) | |||
|---|---|---|---|---|
| 1 and 2 | 3 | 4 | ||
| Range (μg/L) | ≤2.58 | 2.59–4.22 | >4.22 | |
| Events | 4 | 13 | 37 | |
| Person years at risk | 4457 | 2174 | 1975 | |
| Incidence rate (per 1000 person years) | 0.9 | 6.0 | 18.7 | |
| Demographic adjusted,a HR (95% CI) | 1.00 (reference) | 13.4 (4.12 to 43.36) | 50.9 (15.5 to 167.7) | 4.18 (3.05 to 5.73) |
| Plus eGFR and urine albumin,b HR (95% CI) | 1.00 (reference) | 2.42 (0.61 to 9.60) | 3.22 (0.81 to 12.91) | 1.25 (0.82 to 1.90) |
| Plus CVD risk factors,c HR (95% CI) | 1.00 (reference) | 2.36 (0.56 to 9.94) | 2.78 (0.57 to 13.59) | 1.16 (0.69 to 1.95) |
a
Adjusted for age, sex, race, education, urine creatinine, and clinic site.
b
Adjusted for demographic variable plus baseline eGFR and urine albumin.
c
Adjusted for demographic variables eGFR, urine albumin, plus smoking status, pack years, body mass index, diabetes, systolic blood pressure, blood pressure medication use, total cholesterol, lipid medication use, and C-reactive protein.