Table 5.

Association of urine PIIINP with incident CVD, heart failure, and mortality in community-living older adult participants in the CHS

	Urine PIIINP Quartiles				Urine PIIINP Continuous Per SD (3.0 μg/L)
	1	2	3	4
Urine PIIINP range (μg/L)	≤1.39	1.40–2.58	2.59–4.22	> 4.22
Incident CVDa
No. of events	75	64	82	68
No. at risk	204	198	212	177
Incidence rate (per 1000 person years)	39.1	33.8	44.3	48.0
Demographic adjusted,b HR (95% CI)	1.00 (reference)	0.87 (0.62 to 1.23)	1.19 (0.83 to 1.71)	1.18 (0.78 to 1.78)	1.13 (0.97 to 1.31)
Fully adjusted,c HR (95% CI)	1.00 (reference)	0.77 (0.54 to 1.09)	0.90 (0.61 to 1.33)	0.84 (0.54 to 1.32)	1.00 (0.85 to 1.18)
Incident HFd
No. of events	60	63	68	69
No. at risk	217	215	227	213
Incidence rate (per 1000 person years)	28.3	30.8	33.8	41.7
Demographic adjusted,b HR (95% CI)	1.00 (reference)	1.13 (0.78 to 1.62)	1.28 (0.86 to 1.89)	1.44 (0.94 to 2.21)	1.12 (0.96 to 1.32)
Fully adjusted,c HR (95% CI)	1.00 (reference)	0.83 (0.57 to 1.21)	0.79 (0.52 to 1.20)	0.75 (0.47 to 1.19)	0.90 (0.75 to 1.08)
Death
No. of events	163	166	165	200
No. at risk	240	239	240	239
Incidence rate (per 1000 person years)	65.9	68.3	70.4	100.2
Demographic adjusted,b HR (95% CI)	1.00 (reference)	1.11 (0.89 to 1.38)	1.34 (1.05 to 1.72)	1.87 (1.44 to 2.43)	1.29 (1.19 to 1.40)
Fully adjusted,c HR (95% CI)	1.00 (reference)	0.93 (0.74 to 1.18)	1.04 (0.80 to 1.34)	1.30 (0.98 to 1.74)	1.12 (1.03 to 1.23)

^aIncident CVD defined as incident MI, stroke, or CVD death. Persons with prevalent CVD at baseline (n=167) were excluded.

^bAdjusted for age, sex, race, education, clinic site and urine creatinine.

^cAdjusted for age, sex, race, education, clinical site, urine creatinine, eGFR, urine albumin, smoking status, pack years, body mass index, diabetes, systolic blood pressure, blood pressure medication use, total cholesterol, lipid medication use, and C-reactive protein.

^dPersons with prevalent HF at baseline (n=86) were excluded.